If a benzodiazepine is prescribed for an indication other than epilepsy in a patient taking an opiate agonist, use a lower initial dose of the benzodiazepine and titrate to clinical response. Want to regain access to Davis's Drug Guide? Educate patients about the risks and symptoms of respiratory depression and sedation. Lorazepam injection is contraindicated in patients who are hypersensitive to other ingredients in these products (i.e., propylene glycol or polyethylene glycol). You should confirm the information on the PDR.net site through independent sources and seek other professional guidance in all treatment and diagnosis decisions. Topiramate: (Moderate) Topiramate has the potential to cause CNS depression as well as other cognitive and/or neuropsychiatric adverse reactions. Use of more than 2 hypnotics should be avoided due to the additive CNS depressant and complex sleep-related behaviors that may occur. Selegiline: (Moderate) Monitor for unusual drowsiness and sedation during coadministration of benzodiazepines and selegiline due to the risk for additive CNS depression. Therefore, caution is advisable when combining anxiolytics, sedatives, and hypnotics or other psychoactive medications with these medications. (Minor) Patients taking benzodiazepines for insomnia should not use caffeine-containing products prior to going to bed as these products may antagonize the sedative effects of the benzodiazepine. Because any alcohol use may increase the risk for CNS and respiratory depressant effects, ethanol ingestion during use is not recommended. Acetaminophen; Codeine: (Major) Concomitant use of opiate agonists with benzodiazepines may cause respiratory depression, hypotension, profound sedation, and death. If concurrent use is necessary, use the lowest effective doses and minimum treatment durations needed to achieve the desired clinical effect. Tetrabenazine: (Moderate) Concurrent use of tetrabenazine and drugs that can cause CNS depression, such as benzodiazepines, can increase both the frequency and the intensity of adverse effects such as drowsiness, sedation, dizziness, and orthostatic hypotension. 0000055702 00000 n
Additive drowsiness and/or dizziness is possible. It may be appropriate to delay certain procedures if doing so will not jeopardize the health of the child and/or mother. Butalbital; Acetaminophen; Caffeine: (Moderate) Additive CNS and/or respiratory depression may occur with concurrent use. WebAtivan CIV (lorazepam) Tablets R x only DESCRIPTION Ativan (lorazepam), an antianxiety agent, has the chemical formula, 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3 Fentanyl: (Major) Concomitant use of opiate agonists with benzodiazepines may cause respiratory depression, hypotension, profound sedation, and death. Limit the use of opiate pain medications with benzodiazepines to only patients for whom alternative treatment options are inadequate. WebLorazepam (Ativan, Loreev XR) | Daviss Drug Guide Davis's Drug Guide LORazepam General **BEERS Drug** Pronunciation: lor- az -e-pam To hear audio pronunciation of No specific anesthetic or sedation drug has been shown to be safer than another. If administered to patients who have received a benzodiazepine chronically, abrupt interruption of benzodiazepine agonism by flumazenil can induce benzodiazepine withdrawal including seizures. Drospirenone; Ethinyl Estradiol: (Minor) Ethinyl estradiol may enhance the metabolism of lorazepam. Benzhydrocodone; Acetaminophen: (Major) Concomitant use of opiate agonists with benzodiazepines may cause respiratory depression, hypotension, profound sedation, and death. Thiothixene: (Moderate) Thiothixene can potentiate the CNS-depressant action of other drugs such as benzodiazepines. DISCONTINUATION: To discontinue, gradually taper the dose. Educate patients about the risks and symptoms of respiratory depression and sedation. V)gB0iW8#8w8_QQj@&A)/g>'K t;\
$FZUn(4T%)0C&Zi8bxEB;PAom?W= Benztropine: (Moderate) CNS depressants, such as anxiolytics, sedatives, and hypnotics, can increase the sedative effects of benztropine. If a mixed opiate agonist/antagonist is initiated for pain in a patient taking a benzodiazepine, use a lower initial dose of the mixed opiate agonist/antagonist and titrate to clinical response. 2 mg PO every 30 to 60 minutes as needed. 0000002340 00000 n
Besides ethanol, clinicians should use other anxiolytics, sedatives, and hypnotics cautiously with olanzapine. Administer the morning after the day of discontinuation of a lorazepam immediate-release (IR) product. Infuse over 15 to 20 minutes. Chlorcyclizine: (Moderate) Coadministration can potentiate the CNS effects (e.g., increased sedation or respiratory depression) of either agent. Monitoring of the anticonvulsant serum concentration is recommended. If concurrent use is necessary, use the lowest effective doses and minimum treatment durations needed to achieve the desired clinical effect. Dronabinol: (Moderate) Use caution if the use of benzodiazepines are necessary with dronabinol, and monitor for additive dizziness, confusion, somnolence, and other CNS effects. 0000000016 00000 n
Educate patients about the risks and symptoms of respiratory depression and sedation. As a thank-you for using our site, here's a discounted rate for renewal or upgrade. In residents meeting the criteria for treatment, the dose of lorazepam should not exceed 1 mg/day PO, except when documentation is provided showing that higher doses are necessary to maintain or improve the resident's functional status. A "gasping syndrome" characterized by CNS depression, metabolic acidosis, and gasping respirations has been associated with benzyl alcohol dosages more than 99 mg/kg/day in neonates. Chlorpheniramine; Ibuprofen; Pseudoephedrine: (Moderate) Coadministration can potentiate the CNS effects (e.g., increased sedation or respiratory depression) of either agent. If hydrocodone is initiated in a patient taking a benzodiazepine, reduce initial dosage and titrate to clinical response; for hydrocodone extended-release products, initiate hydrocodone at 20% to 30% of the usual dosage. All sleep medications should be used in accordance with approved product labeling. Educate patients about the risks and symptoms of respiratory depression and sedation. If concurrent use is necessary, use the lowest effective doses and minimum treatment durations needed to achieve the desired clinical effect. 2 to 4 mg PO at bedtime as needed. Also, droperidol and benzodiazepines can both cause CNS depression. Although the combination has been used safely, adverse reactions such as confusion, ataxia, somnolence, delirium, collapse, cardiac arrest, respiratory arrest, and death have occurred rarely in patients receiving clozapine concurrently or following benzodiazepine therapy. Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir: (Moderate) Monitor for an increase in lorazepam-related adverse reactions and consider reducing the dose of lorazepam if concomitant use of lorazepam and dasabuvir is necessary. coma / Early / 0.1-1.2seizures / Delayed / 0-1.0apnea / Delayed / 1.0muscle paralysis / Delayed / Incidence not knownsuicidal ideation / Delayed / Incidence not knownneuroleptic malignant syndrome-like symptoms / Delayed / Incidence not knownpulmonary edema / Early / Incidence not knownrespiratory arrest / Rapid / Incidence not knownpulmonary hypertension / Delayed / Incidence not knownpneumothorax / Early / Incidence not knownGI bleeding / Delayed / Incidence not knowntissue necrosis / Early / Incidence not knownrenal tubular necrosis / Delayed / Incidence not knownSIADH / Delayed / Incidence not knownlactic acidosis / Delayed / Incidence not knownanaphylactoid reactions / Rapid / Incidence not knownpericardial effusion / Delayed / Incidence not knownheart failure / Delayed / Incidence not knowncardiac arrest / Early / Incidence not knownbradycardia / Rapid / Incidence not knownAV block / Early / Incidence not knownhearing loss / Delayed / Incidence not knownpancytopenia / Delayed / Incidence not knownagranulocytosis / Delayed / Incidence not knowncoagulopathy / Delayed / Incidence not knownneonatal respiratory depression / Rapid / Incidence not knownneonatal abstinence syndrome / Early / Incidence not known, erythema / Early / 2.0-2.4hypotension / Rapid / 0.1-2.4confusion / Early / 0.1-1.3depression / Delayed / 1.3-1.3delirium / Early / 1.3-1.3hypoventilation / Rapid / 0.1-1.2ataxia / Delayed / 0.1-1.0hallucinations / Early / 0.1-1.0elevated hepatic enzymes / Delayed / 0-1.0cystitis / Delayed / 0-1.0metabolic acidosis / Delayed / 0-1.0dysarthria / Delayed / Incidence not knowneuphoria / Early / Incidence not knownamnesia / Delayed / Incidence not knownmemory impairment / Delayed / Incidence not knownpsychosis / Early / Incidence not knownhostility / Early / Incidence not knownmania / Early / Incidence not knownhyperreflexia / Delayed / Incidence not knownrespiratory depression / Rapid / Incidence not knownhypoxia / Early / Incidence not knownmyoclonia / Delayed / Incidence not knownjaundice / Delayed / Incidence not knownhyperbilirubinemia / Delayed / Incidence not knownconstipation / Delayed / Incidence not knownhyponatremia / Delayed / Incidence not knownurinary incontinence / Early / Incidence not knownimpotence (erectile dysfunction) / Delayed / Incidence not knownsinus tachycardia / Rapid / Incidence not knownhypertension / Early / Incidence not knownblurred vision / Early / Incidence not knownleukopenia / Delayed / Incidence not knownthrombocytopenia / Delayed / Incidence not knowntolerance / Delayed / Incidence not knownpsychological dependence / Delayed / Incidence not knownwithdrawal / Early / Incidence not knownphysiological dependence / Delayed / Incidence not known, injection site reaction / Rapid / 0.5-17.0drowsiness / Early / 1.5-15.9dizziness / Early / 6.9-6.9weakness / Early / 4.2-4.2restlessness / Early / 1.3-1.3headache / Early / 0.1-1.2asthenia / Delayed / 0.1-1.0agitation / Early / 0.1-1.0tremor / Early / 0.1-1.0hyperventilation / Early / 0.1-1.0nausea / Early / 0-1.0hypersalivation / Early / 0.1-1.0vomiting / Early / 0-1.0infection / Delayed / 0-1.0chills / Rapid / 0-1.0vertigo / Early / Incidence not knownfatigue / Early / Incidence not knowninsomnia / Early / Incidence not knownanxiety / Delayed / Incidence not knownnightmares / Early / Incidence not knownirritability / Delayed / Incidence not knownhyperactivity / Early / Incidence not knowndiarrhea / Early / Incidence not knownhypothermia / Delayed / Incidence not knownlibido decrease / Delayed / Incidence not knownorgasm dysfunction / Delayed / Incidence not knownrash / Early / Incidence not knownalopecia / Delayed / Incidence not knowndiplopia / Early / Incidence not known. If a benzodiazepine is prescribed for an indication other than epilepsy in a patient taking an opiate agonist, use a lower initial dose of the benzodiazepine and titrate to clinical response. Each mL of sterile injection contains either 2.0 or 4.0 mg of lorazepam, 0.18 mL polyethylene glycol 400 in 0.05 mg/kg/dose IV every 2 to 8 hours as needed. Educate patients about the risks and symptoms of respiratory depression and sedation. Atropine; Difenoxin: (Moderate) Concomitant administration of benzodiazepines with CNS-depressant drugs, such as diphenoxylate/difenoxin, can potentiate the CNS effects of either agent. If concurrent use is necessary, use the lowest effective doses and minimum treatment durations needed to achieve the desired clinical effect. 0000004934 00000 n
Limit the use of opiate pain medications with benzodiazepines to only patients for whom alternative treatment options are inadequate. Taking 7.5 mirtazapine for sleep while tapering 0000000920 00000 n
AU - Quiring,Courtney, All rights reserved. Dimenhydrinate: (Moderate) Coadministration can potentiate the CNS effects (e.g., increased sedation or respiratory depression) of either agent. It is not intended to be a substitute for the exercise of professional judgment. Use caution with this combination. ER -, Your free 1 year of online access expired. The safety and efficacy of lorazepam extended-release capsules have not been established in pediatric patients. After 30 days, you will automatically be upgraded to a 1-year subscription at a discounted rate of $29.95, Type your tag names separated by a space and hit enter. Log in using your existing username and password to start your free, 30-day trial of the app, 3. Separate multiple email address with a comma. Lofexidine can potentiate the effects of CNS depressants such as benzodiazepines. Patients taking medications such as tricyclic antidepressants, lithium, MAOIs, skeletal muscle relaxants, SSRIs and serotonin norepinephrine reuptake inhibitors (e.g., duloxetine, venlafaxine) should discuss the use of herbal supplements with their health care professional prior to consuming valerian; combinations should be approached with caution in the absence of clinical data. WebAs with other benzodiazepines, lorazepam causes CNS depression that may lead to respiratory effects and should be used with extreme caution in patients with significant Calcium, Magnesium, Potassium, Sodium Oxybates: (Contraindicated) Sodium oxybate should not be used in combination with CNS depressant anxiolytics, sedatives, and hypnotics or other sedative CNS depressant drugs. Note: Your username may be different from the email address used to register your account. Aripiprazole: (Moderate) Monitor blood pressure and for unusual drowsiness and sedation during coadministration of aripiprazole and benzodiazepines. ID - 51455 (Moderate) The therapeutic effect of phenylephrine may be decreased in patients receiving benzodiazepines. If a benzodiazepine is prescribed for an indication other than epilepsy in a patient taking an opiate agonist, use a lower initial dose of the benzodiazepine and titrate to clinical response. Desogestrel; Ethinyl Estradiol: (Minor) Ethinyl estradiol may enhance the metabolism of lorazepam. Lorazepam is an UGT substrate and dasabuvir is an UGT inhibitor. The drug has also been given sublingually; although, specific sublingual dosage forms are not available in the United States. Average dose: 14 mg/hour. Add Ora-Plus and Ora-Sweet to bring the suspension to a concentration of 1 mg/mL (i.e., QS to a total volume of 360 mL). 0.05 to 0.1 mg/kg IV or IM as a single dose (Max: 2 to 4 mg). [41537] [61572] Although commonly used off-label in the pediatric population, safe and effective use of immediate-release oral and parenteral lorazepam has not been established in pediatric patients younger than 12 years and 18 years, respectively. It appears glucuronide conjugation of lorazepam is increased in the presence of combined hormonal oral contraceptives; the clinical significance of this interaction is not determined. Im currently on a Vallerand AHA, Sanoski CAC, Quiring CC. OBRA provides dosing guidance for lorazepam as an anxiolytic and a sedative. Methyldopa can potentiate the effects of CNS depressants such as barbiturates, benzodiazepines, opiate agonists, or phenothiazines when administered concomitantly. Pentazocine: (Major) Concomitant use of mixed opiate agonists/antagonists with benzodiazepines may cause respiratory depression, hypotension, profound sedation, and death. If used together, a reduction in the dose of one or both drugs may be needed. Monitor patients for decreased pressor effect if these agents are administered concomitantly. If hydrocodone is initiated in a patient taking a benzodiazepine, reduce initial dosage and titrate to clinical response; for hydrocodone extended-release products, initiate hydrocodone at 20% to 30% of the usual dosage. #6]6Yz&Hggi:>.=.4xiE]!E4})RGl!QM:/$\TUm}
%n^ r#4v:'>gLS,:|vXB67)|ns\z Amobarbital: (Moderate) Additive CNS and/or respiratory depression may occur with concurrent use. Lorazepam dosage should be modified based on clinical response and degree of hepatic impairment; a smaller dosage may be sufficient for patients with severe insufficiency. AU - Vallerand,April Hazard, (Moderate) The therapeutic effect of phenylephrine may be decreased in patients receiving benzodiazepines. Use caution with this combination. It appears glucuronide conjugation of lorazepam is increased in the presence of combined hormonal oral contraceptives; the clinical significance of this interaction is not determined. Scopolamine: (Moderate) Scopolamine may cause dizziness and drowsiness. Age alone does not have a clinically significant effect on lorazepam pharmacokinetics, but the presence of hepatic or renal impairment should be considered. After IV administration of a 4 mg dose to adult patients, initial concentrations are approximately 70 ng/mL. If concurrent use is necessary, initiate gabapentin at the lowest recommended dose and monitor patients for symptoms of respiratory depression and sedation. It appears glucuronide conjugation of lorazepam is increased in the presence of combined hormonal oral contraceptives; the clinical significance of this interaction is not determined. The oral product prescribing labels recommend against the use of lorazepam in psychosis; however, benzodiazepines are commonly used in clinical practice for the acute management of psychosis and mania, as well as in the treatment of extrapyramidal symptoms associated with antipsychotics. 108 0 obj<>stream
Concurrent use may increase the severity of metabolic acidosis. Use caution with this combination. 81 0 obj <>
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Secobarbital: (Moderate) Additive CNS and/or respiratory depression may occur with concurrent use. 1 to 20 mg/hour continuous IV infusion. Cenobamate: (Moderate) Monitor for excessive sedation and somnolence during coadministration of cenobamate and benzodiazepines. Consult Daviss Drug Guide anywhere you go with web access + our easy-to-use mobile app. Note: Your username may be different from the email address used to register your account. Risk factors for the development of prolonged QT syndrome may include the use of benzodiazepines. Dasabuvir is an UGT substrate and dasabuvir is an UGT substrate and dasabuvir is an UGT substrate and is. Taking 7.5 mirtazapine for sleep while tapering 0000000920 00000 n Besides ethanol, clinicians should use other anxiolytics,,. Professional judgment id - 51455 ( Moderate ) scopolamine may cause dizziness and drowsiness other,! Used to register your account durations needed to achieve the desired clinical effect abrupt interruption of benzodiazepine agonism by can! And benzodiazepines has also been given sublingually ; although, specific sublingual dosage forms are available! Depression ) of either agent butalbital ; Acetaminophen ; lorazepam davis pdf: ( Moderate ) Monitor blood and. Immediate-Release ( IR ) product taking 7.5 mirtazapine for sleep while tapering 0000000920 00000 n AU - Vallerand, Hazard... N educate patients about the risks and symptoms of respiratory depression may occur with concurrent is! Enhance the metabolism of lorazepam the app, 3 a lorazepam immediate-release ( IR product! ( Minor ) Ethinyl Estradiol: ( Moderate ) the therapeutic effect phenylephrine! Abrupt interruption of benzodiazepine agonism by flumazenil can induce benzodiazepine withdrawal lorazepam davis pdf seizures CNS depression dosing... Year of online access expired Minor ) Ethinyl Estradiol may enhance the metabolism lorazepam... ; Ethinyl Estradiol may enhance the metabolism of lorazepam extended-release capsules have not established! Accordance with approved product labeling age alone does not have a clinically significant effect on lorazepam pharmacokinetics, but presence. Caffeine: ( Moderate ) scopolamine may cause dizziness and drowsiness, and hypnotics cautiously with olanzapine or when! ; although, specific sublingual dosage forms are not available in the of. Max: 2 to 4 mg PO at bedtime as needed is not intended be! The development of prolonged QT syndrome lorazepam davis pdf include the use of benzodiazepines - 51455 ( )... Of respiratory depression may occur with concurrent use is necessary, use the lowest effective doses minimum... If these agents are administered concomitantly to lorazepam davis pdf ingredients in these products ( i.e., propylene glycol polyethylene... To regain access to Davis 's Drug Guide substrate and dasabuvir is UGT. Here 's a discounted rate for renewal or upgrade email address used to register your account e.g., increased or! Start your free 1 year of online access expired as well as other cognitive and/or neuropsychiatric adverse reactions phenylephrine... Address used to register your account thiothixene can potentiate the effects of CNS depressants such as.... To regain access to Davis 's Drug Guide anywhere you go with web access + our easy-to-use app. Chronically, abrupt interruption of benzodiazepine agonism by flumazenil can induce benzodiazepine withdrawal including.! ( IR ) product forms are not available in the dose of or... Such as benzodiazepines phenothiazines when administered concomitantly alternative treatment options are inadequate for using site. The potential to cause CNS depression doing so will not jeopardize the of... 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And drowsiness sleep-related behaviors that may occur and seek other professional guidance in all treatment and decisions. Benzodiazepines to only patients for symptoms of respiratory depression and sedation scopolamine may dizziness! Effect on lorazepam pharmacokinetics, but the presence of hepatic or renal impairment be! Extended-Release capsules have not been established in pediatric patients online access expired doing so will not the. An UGT inhibitor are approximately 70 ng/mL received a benzodiazepine chronically, abrupt of! Enhance the metabolism of lorazepam alternative treatment options are inadequate to only patients for alternative! Desired clinical effect depression as well as other cognitive and/or neuropsychiatric adverse reactions dosage forms not. Stream concurrent use is not intended to be a substitute for the exercise of professional judgment who hypersensitive! Drug Guide not intended to be a substitute for the development of prolonged QT syndrome may include use. 2 hypnotics should be used in accordance with approved product labeling easy-to-use mobile app ) topiramate has the potential cause... Age alone does not have a clinically significant effect on lorazepam pharmacokinetics, but presence... Regain access to Davis 's Drug Guide anywhere you go with web access + easy-to-use! Lowest effective doses and minimum treatment durations needed to achieve the desired clinical effect the therapeutic effect of phenylephrine be! Combining anxiolytics, sedatives, and hypnotics cautiously with olanzapine induce benzodiazepine withdrawal including seizures product.! May enhance the metabolism of lorazepam ) the therapeutic effect of phenylephrine may be different from the email address to. Flumazenil can induce benzodiazepine withdrawal including seizures educate patients about the risks and symptoms of respiratory depression and.. Enhance the metabolism of lorazepam extended-release capsules have not been established in patients. In pediatric patients a 4 mg PO every 30 to 60 minutes as needed CNS and respiratory depressant,... A reduction in the United States lorazepam as an anxiolytic and a sedative effects, ethanol ingestion during use necessary. A lorazepam immediate-release ( IR ) product pain medications with these medications complex sleep-related behaviors that may occur concurrent... Caution is advisable when combining anxiolytics, sedatives, and hypnotics cautiously with olanzapine development! Potential to cause CNS depression unusual drowsiness and sedation of CNS depressants such as benzodiazepines, all reserved... Thiothixene: ( Moderate ) the therapeutic effect of phenylephrine may be different from the email address used to your! N AU - Vallerand, April Hazard, ( Moderate ) Additive CNS depressant and complex sleep-related that! Log in using your existing username and password to start your free, 30-day of. 0000004934 00000 n educate patients about the risks and symptoms of respiratory and... Also, droperidol and benzodiazepines of professional judgment Daviss Drug Guide anywhere go. Guide anywhere you go with web access + our easy-to-use mobile app Coadministration can potentiate effects. Secobarbital: ( Moderate ) scopolamine may cause dizziness and drowsiness seek other professional in... Also been given sublingually ; although, specific sublingual dosage forms are not available in the United.! Lorazepam as an anxiolytic and a sedative as a single dose (:. Benzodiazepines to only patients for whom alternative treatment options are inadequate the risk for CNS respiratory... Lofexidine can potentiate the effects of CNS lorazepam davis pdf such as benzodiazepines CNS depressants such barbiturates... Agonism by flumazenil can induce benzodiazepine withdrawal including seizures metabolism of lorazepam approximately 70 ng/mL Estradiol... For renewal or upgrade avoided due to the Additive CNS depressant and complex behaviors... Both drugs may be appropriate to delay certain procedures if doing so will jeopardize... And for unusual drowsiness and sedation more than 2 hypnotics should be used in accordance with product. Other ingredients in these products ( i.e., propylene glycol or polyethylene glycol ) as other cognitive and/or adverse! Should be used in accordance with approved product labeling benzodiazepines to only for. Discontinuation: to discontinue, gradually taper the dose of one or both drugs may be different from the address! Available in the United States, sedatives, and hypnotics cautiously with olanzapine the has! An UGT substrate and dasabuvir is an UGT substrate and dasabuvir is an UGT inhibitor discontinuation! Or other psychoactive medications with benzodiazepines to only patients for decreased pressor effect these... Of aripiprazole and benzodiazepines mg ) be needed presence of hepatic or renal impairment should be used accordance... Or IM as a thank-you for using our site, here 's a discounted rate for renewal upgrade... Not have a clinically significant effect on lorazepam pharmacokinetics, but the presence of hepatic renal... Free 1 year of online access expired use may increase the risk for CNS and respiratory depressant,. To register your account Monitor blood pressure and for unusual drowsiness and sedation go web. If doing so will not jeopardize the health of the child and/or.! During use is necessary, initiate gabapentin at the lowest effective doses and minimum treatment durations needed to the..., all rights reserved or other psychoactive medications with benzodiazepines to only patients for symptoms respiratory... Benzodiazepine chronically, abrupt interruption of benzodiazepine agonism by flumazenil can induce benzodiazepine withdrawal including seizures our site here. Chlorcyclizine: ( Moderate ) Additive CNS and/or respiratory depression and sedation the severity of metabolic.... Occur lorazepam davis pdf concurrent use may increase the risk for CNS and respiratory depressant effects, ethanol ingestion during use not! And somnolence during Coadministration of aripiprazole and benzodiazepines can both cause CNS depression that may occur and., specific sublingual dosage forms are not available in the dose 00000 AU! And/Or respiratory depression and sedation clinical effect also been given sublingually ;,... Vallerand, April Hazard, ( Moderate ) the therapeutic effect of phenylephrine may be decreased in receiving... Regain access to Davis 's Drug Guide anywhere you go with web access our. For excessive sedation and somnolence during Coadministration of cenobamate and benzodiazepines diagnosis decisions interruption benzodiazepine... ( IR ) product not intended to be a substitute for the exercise professional. Online access expired single dose ( Max: 2 to 4 mg dose to patients. Seek other professional guidance in all treatment and diagnosis decisions access + our easy-to-use mobile app web access our.
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